This is particularly legitimate of Reverse Osmosis (RO) systems. It's been recognized that since Reverse Osmosis filters are usually not complete, it may be necessary to have them in collection as a way to manufacture pyrogen-free WFI.
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Traditionally, vials or glass factors happen to be rendered pyrogen-cost-free by dry warmth sterilization at high temperatures. Some texts have encouraged the depyrogenation of glassware and gear by heating at a temperature of 250 C for 45 minutes.
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